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Article

Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells

17 Dec 2012

Abstract excerpt

PURPOSE: Klotho has been identified as a tumor suppressor in several human malignancies including hepatocellular carcinoma (HCC). However, the signaling pathways involved in the tumor suppressive role of klotho in HCC have not been reported. Here, we investigated the role of klotho in HCC cell proliferation, apoptosis, autophagy, and invasion, as well as its associated signal transduction pathways. METHODS:...

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PMID: 23248036
DOI: 10.1007/s13402-012-0118-0

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