Article
The Role of Alpha-Klotho as a Universal Tumor Suppressor.
Vitamins and hormones - 1 Jan 2016
Rubinek T, Wolf I
Abstract excerpt
The klotho gene is implicated in many physiological activities, among them aging, glucose metabolism, and phosphate and calcium metabolism. Many cellular activities of klotho were implicated in promoting these activities. Two of them, inhibition of the insulin-like growth factor-1 pathway and of the Wnt signaling pathway, are also major pathways associated with cancer development and progression. These...
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