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The Antiaging Gene Klotho Regulates Proliferation and Differentiation of Adipose-Derived Stem Cells

11 Feb 2016

Abstract excerpt

Klotho was originally discovered as an aging-suppressor gene. The purpose of this study was to investigate whether secreted Klotho (SKL) affects the proliferation and differentiation of adipose-derived stem cells (ADSCs). RT-PCR and Western blot analysis showed that short-form Klotho was expressed in mouse ADSCs. The Klotho gene mutation KL(-/-) significantly decreased proliferation of ADSCs and expression of...

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PMID: 26865060
DOI: 10.1002/stem.2305

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