Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling

30 Jul 2018

Abstract excerpt

BACKGROUND: Gastrointestinal stromal tumour (GIST) is the most common soft tissue sarcoma. The identification of the molecular mechanisms regulating GIST progression is vital for its treatment and prevention. Increasing reports have demonstrated that epigenetic alterations play critical roles in GIST development. However, the role of the histone demethylase KDM4D in GIST progression is poorly understood. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Remodeling and Cancer
Share to Epigenetics and DNA Methylation
Share to Gastrointestinal Tumor Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30060750
DOI: 10.1186/s12943-018-0861-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signallingPMID 30060750Read ↗

Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stabilitySemantic proximity Read ↗

KDM1 is a novel therapeutic target for the treatment of gliomasSemantic proximity Read ↗

Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-MycSemantic proximity Read ↗

Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumorsSemantic proximity Read ↗

SETD2 histone modifier loss in aggressive GI stromal tumours.Semantic proximity Read ↗

MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib Resistance by Targeting KDM4D ExpressionSemantic proximity Read ↗

ETV4 collaborates with Wnt/β-catenin signaling to alter cell cycle activity and promote tumor aggressiveness in gastrointestinal stromal tumorSemantic proximity Read ↗

KDM2B overexpression correlates with poor prognosis and regulates glioma cell growthSemantic proximity Read ↗

DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors.Semantic proximity Read ↗

Targeting glioma stem‐like cell survival and chemoresistance through inhibition of lysine‐specific histone demethylase KDM 2BSemantic proximity Read ↗

Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression.Semantic proximity Read ↗

SMYD2 aggravates gastrointestinal stromal tumor via upregulation of EZH2 and downregulation of TET1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.