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Article

Denosumab treated giant cell tumour of bone: a morphological, immunohistochemical and molecular analysis of a series.

Journal of clinical pathology - 1 Mar 2016

Girolami Ilaria, Mancini Irene, Simoni Antonella, Baldi Giacomo Giulio, Simi Lisa, Campanacci Domenico, Beltrami Giovanni, Scoccianti Guido, D'Arienzo Antonio, Capanna Rodolfo, Franchi Alessandro

Abstract excerpt

AIMS: Denosumab, a fully human monoclonal antibody directed against RANKL, has recently been introduced in the treatment strategy of giant cell tumour of bone (GCTB). Aim of this study was to investigate the phenotypical modifications induced by denosumab treatment in a series of 15 GCTB. METHODS: The tumours were characterised for histone 3.3 mutations, and studied immunohistochemically for the modifications of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26338802
DOI: 10.1136/jclinpath-2015-203248

Genes

RUNX2
SATB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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