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Article

DIGGIT: a Bioconductor package to infer genetic variants driving cellular phenotypes.

Bioinformatics (Oxford, England) - 15 Dec 2015

Alvarez Mariano J, Chen James C, Califano Andrea

Abstract excerpt

UNLABELLED: Identification of driver mutations in human diseases is often limited by cohort size and availability of appropriate statistical models. We propose a method for the systematic discovery of genetic alterations that are causal determinants of disease, by prioritizing genes upstream of functional disease drivers, within regulatory networks inferred de novo from experimental data. Here we present the...

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PMID: 26338767
DOI: 10.1093/bioinformatics/btv499
PMCID: PMC4692968

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