Article
FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseases.
Genome biology - 2 Jan 2024
Breeze Charles E, Haugen Eric, Gutierrez-Arcelus María, Yao Xiaozheng, Teschendorff Andrew, Beck Stephan, Dunham Ian, Stamatoyannopoulos John, Franceschini Nora, Machiela Mitchell J, Berndt Sonja I
Abstract excerpt
The majority of disease-associated variants identified through genome-wide association studies are located outside of protein-coding regions. Prioritizing candidate regulatory variants and gene targets to identify potential biological mechanisms for further functional experiments can be challenging. To address this challenge, we developed FORGEdb ( https://forgedb.cancer.gov/ ;...
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