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Article

Leverage Large-Scale Biological Networks to Decipher the Genetic Basis of Human Diseases Using Machine Learning.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Wang Hao, Yang Jiaxin, Wang Jianrong

Abstract excerpt

A fundamental question in precision medicine is to quantitatively decode the genetic basis of complex human diseases, which will enable the development of predictive models of disease risks based on personal genome sequences. To account for the complex systems within different cellular contexts, large-scale regulatory networks are critical components to be integrated into the analysis. Based on the fast...

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Algorithms
Computational Biology
Genetic Predisposition to Disease
Genetic Variation
Genome

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Machine Learning

Neural Networks, Computer

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PMID: 32804369
DOI: 10.1007/978-1-0716-0826-5_11
PMCID: PMC7433890

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