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Article

Mitochondrial and inflammatory changes in sporadic inclusion body myositis.

Neuropathology and applied neurobiology - 1 Apr 2015

Rygiel Karolina A, Miller James, Grady John P, Rocha Mariana C, Taylor Robert W, Turnbull Doug M

Abstract excerpt

AIMS: Sporadic inclusion body myositis (sIBM) is the most common late onset muscle disease causing progressive weakness. In light of the lack of effective treatment, we investigated potential causes underlying muscle wasting. We hypothesized that accumulation of mitochondrial respiratory deficiency in muscle fibres may lead to fibre atrophy and degeneration, contributing to muscle mass reduction. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24750247
DOI: 10.1111/nan.12149
PMCID: PMC4833191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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