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Article

The role of the mtDNA set point in differentiation, development and tumorigenesis.

The Biochemical journal - 1 Oct 2016

Sun Xin, St John Justin C

Abstract excerpt

Mitochondrial DNA replication is critical for maintaining mtDNA copy number to generate sufficient cellular energy that is required for development and for functional cells. In early development, mtDNA copy number is strictly regulated at different stages, and, as a result, the establishment of the mtDNA set point is required for sequential cell lineage commitment. The failure to establish the mtDNA set point...

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Share to Carcinogenesis
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Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oxidative Phosphorylation

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Source

Identifiers

PMID: 27679856
DOI: 10.1042/BCJ20160008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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