Article
No correlation between mtDNA amount and methylation levels at the CpG island of POLG exon 2 in wild-type and mutant human differentiated cells.
Journal of medical genetics - 1 May 2017
Steffann Julie, Pouliet Aurore, Adjal Houda, Bole Christine, Fourrage Cécile, Martinovic Jelena, Rolland-Galmiche Louise, Rotig Agnes, Tores Frédéric, Munnich Arnold, Bonnefont Jean-Paul
Abstract excerpt
BACKGROUND: While mitochondrial DNA (mtDNA) copy number is strictly regulated during differentiation and according to cell type, very little is known regarding the mechanism which accurately controls mtDNA copy number in human. Exon 2 of the human POLG gene, encoding the catalytic subunit of the mitochondrial-specific DNA polymerase gamma, contains a CpG island, highly conserved in mice and human. Changes of DNA...
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