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Estimation of blood cellular heterogeneity in newborns and children for epigenome‐wide association studies

31 Aug 2015

Abstract excerpt

Confounding by cellular heterogeneity has become a major concern for epigenome-wide association studies (EWAS) in peripheral blood samples from population and clinical studies. Adjusting for white blood cell percentage estimates produced by the minfi implementation of the Houseman algorithm (minfi) during statistical analysis is now an established method to account for this bias in adults. However, minfi has not...

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PMID: 26332589
DOI: 10.1002/em.21966

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