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Article

Heterogeneity in white blood cells has potential to confound DNA methylation measurements.

PloS one - 1 Jan 2012

Adalsteinsson Bjorn T, Gudnason Haukur, Aspelund Thor, Harris Tamara B, Launer Lenore J, Eiriksdottir Gudny, Smith Albert V, Gudnason Vilmundur

Abstract excerpt

Epigenetic studies are commonly conducted on DNA from tissue samples. However, tissues are ensembles of cells that may each have their own epigenetic profile, and therefore inter-individual cellular heterogeneity may compromise these studies. Here, we explore the potential for such confounding on DNA methylation measurement outcomes when using DNA from whole blood. DNA methylation was measured using...

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Identifiers

PMID: 23071618
DOI: 10.1371/journal.pone.0046705
PMCID: PMC3465258

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HHEX
KCNJ11
KCNQ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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