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Article

Accounting for cellular heterogeneity is critical in epigenome-wide association studies.

Genome biology - 4 Feb 2014

Jaffe Andrew E, Irizarry Rafael A

Abstract excerpt

BACKGROUND: Epigenome-wide association studies of human disease and other quantitative traits are becoming increasingly common. A series of papers reporting age-related changes in DNA methylation profiles in peripheral blood have already been published. However, blood is a heterogeneous collection of different cell types, each with a very different DNA methylation profile. RESULTS: Using a statistical method that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24495553
DOI: 10.1186/gb-2014-15-2-r31
PMCID: PMC4053810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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