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Article

High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa.

PloS one - 1 Jan 2015

Niehaus Abraham J, Mlisana Koleka, Gandhi Neel R, Mathema Barun, Brust James C M

Abstract excerpt

BACKGROUND: Drug-resistant tuberculosis (TB) remains extremely difficult to treat because there are often few remaining active medications and limited diagnostic options to detect resistance. Resistance to isoniazid is typically caused by mutations in either katG or the inhA promoter. inhA mutations confer low-level resistance to isoniazid and cross-resistance to ethionamide while katG mutations confer high-level...

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PMID: 26332235
DOI: 10.1371/journal.pone.0135003
PMCID: PMC4557915

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LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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