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Article

KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice.

PLoS pathogens - 1 Sept 2015

Sin Sang-Hoon, Kim Yongbaek, Eason Anthony, Dittmer Dirk P

Abstract excerpt

Kaposi sarcoma-associated herpesvirus (KSHV) has been linked to Kaposi sarcoma and B-cell malignancies. Mechanisms of KSHV-induced oncogenesis remain elusive, however, in part due to lack of reliable in vivo models. Recently, we showed that transgenic mice expressing the KSHV latent genes, including all viral microRNAs, developed splenic B cell hyperplasia with 100% penetrance, but only a fraction converted to B...

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Source

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Identifiers

PMID: 26327622
DOI: 10.1371/journal.ppat.1005135
PMCID: PMC4556645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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