Article

Kaposi Sarcoma herpesvirus reactivation and replication are dispensable for cell-lineage specific tumorigenesis in whole genome transgenic mice

2026-06-14

Abstract excerpt

Herpesvirus reactivation and replication depend on an ordered cascade of gene expression. The viral immediate-early replication and transcription activator protein (Rta) is necessary and sufficient to initiate this process. For Kaposi sarcoma herpesvirus (KSHV), Rta-interacting and Rta-regulated proteins are thought to contribute to cellular transformation. Using a novel, whole-genome transgenic mouse model, we sh...

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Literature Corpus work: 900f51fd-400e-584d-b361-4f044e41ee0d
DOI: 10.64898/2026.06.10.731437

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