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Article

Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma.

Blood - 23 Jan 2014

Fish Kamonwan, Chen Jia, Longnecker Richard

Abstract excerpt

Elevated expression of MYC is a shared property of many human cancers. Epstein-Barr virus (EBV) has been associated with lymphoid malignancies, yet collaborative roles between MYC and EBV in lymphomagenesis are unclear. EBV latent membrane protein 2A (LMP2A) functions as a B-cell receptor (BCR) mimic known to provide survival signals to infected B cells. Co-expression of human MYC and LMP2A in mice (LMP2A/λ-MYC)...

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Topics

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Share to Active Transport, Cell Nucleus
Share to Cell Cycle
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Lymphoma

Share to Lymphoma, B-Cell

Share to Proto-Oncogene Proteins c-myc

Share to Viral Matrix Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24174629
DOI: 10.1182/blood-2013-07-517649
PMCID: PMC3901066

Genes

MYC
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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