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Article

Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma.

Blood - 23 Jan 2014

Fish Kamonwan, Chen Jia, Longnecker Richard

Abstract excerpt

Elevated expression of MYC is a shared property of many human cancers. Epstein-Barr virus (EBV) has been associated with lymphoid malignancies, yet collaborative roles between MYC and EBV in lymphomagenesis are unclear. EBV latent membrane protein 2A (LMP2A) functions as a B-cell receptor (BCR) mimic known to provide survival signals to infected B cells. Co-expression of human MYC and LMP2A in mice (LMP2A/λ-MYC)...

Topics

Active Transport, Cell Nucleus
Animals
Apoptosis
Cell Cycle
Cell Proliferation
Cell Transformation, Neoplastic
Cyclin-Dependent Kinase Inhibitor p27
Disease Models, Animal
Flow Cytometry
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Humans

Lymphoma

Lymphoma, B-Cell

Mice

Mice, Inbred C57BL

Mice, Transgenic

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 24174629
DOI: 10.1182/blood-2013-07-517649
PMCID: PMC3901066

Genes

MYC
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma.PMID 24174629Read ↗

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