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Article

Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis.

Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2009

Bieging Kathryn T, Amick Alexandra C, Longnecker Richard

Abstract excerpt

Although Epstein-Barr virus (EBV) is linked to Burkitt's lymphoma (BL), the role of the virus in lymphomagenesis is unclear. LMP2A, encoded by EBV, can be detected in BL biopsies and has prosurvival functions. We generated mice expressing MYC and LMP2A in B cells. LMP2A/lambda-MYC mice show greatly accelerated tumor onset. Similar to previous work, we found p53 mutations in lambda-MYC tumors; however, we detected...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19815507
DOI: 10.1073/pnas.0907994106
PMCID: PMC2764894

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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