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Latent membrane proteins from EBV differentially target cellular pathways to accelerate MYC-induced lymphomagenesis

23 May 2022

Abstract excerpt

MYC translocations in association with Epstein-Barr virus (EBV) infection are often observed in B-cell lymphomas. A subset of Burkitt lymphoma (BL) expresses EBV latent membrane proteins 1 and 2A (LMP1 and LMP2A) in addition to the typical restricted EBV latent gene expression. EBV-associated diffuse large B-cell lymphoma (DLBCL) typically exhibits latency type II or III and expresses LMP1. Here, we investigate...

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PMID: 35605249
DOI: 10.1182/bloodadvances.2022007695

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