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Article

Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP.

Biochimica et biophysica acta - 1 Nov 2015

Häfner Ann-Kathrin, Gerstmeier Jana, Hörnig Michael, George Sven, Ball Ann-Katrin, Schröder Mirjam, Garscha Ulrike, Werz Oliver, Steinhilber Dieter

Abstract excerpt

Human 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes (LTs), important mediators of inflammation. Cellular 5-LO activity is regulated in a complex manner, e.g. by calcium influx, the cellular redox status or 5-LO phosphorylation. Being a mobile enzyme, 5-LO migrates from the cytosol to the nuclear envelope where it is believed to interact with 5-lipoxygenase-activating protein (FLAP) and...

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PMID: 26327594
DOI: 10.1016/j.bbalip.2015.08.010

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