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Article

The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation.

The Journal of biological chemistry - 5 Jan 2001

Chen X S, Funk C D

Abstract excerpt

5-Lipoxygenase is the key enzyme in the formation of leukotrienes, which are potent lipid mediators of asthma pathophysiology. This enzyme translocates to the nuclear envelope in a calcium-dependent manner for leukotriene biosynthesis. Eight green fluorescent protein (GFP)-lipoxygenase constructs, representing the major human and mouse enzymes within this family, were constructed and their cDNAs transfected into...

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Identifiers

PMID: 11042185
DOI: 10.1074/jbc.M008203200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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