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Article

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.

Nature cell biology - 12 Jun 2011

Ferreira Helder C, Luke Brian, Schober Heiko, Kalck Véronique, Lingner Joachim, Gasser Susan M

Abstract excerpt

Budding yeast telomeres are reversibly bound at the nuclear envelope through two partially redundant pathways that involve the Sir2/3/4 silencing complex and the Yku70/80 heterodimer. To better understand how this is regulated, we studied the role of SUMOylation in telomere anchoring. We find that the PIAS-like SUMO E3 ligase Siz2 sumoylates both Yku70/80 and Sir4 in vivo and promotes telomere anchoring to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

Identifiers

PMID: 21666682
DOI: 10.1038/ncb2263

Genes

PIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.PMID 21666682Read ↗

Role of SUMO in the dynamics of telomere maintenance in fission yeast.Semantic proximity Read ↗

Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.Semantic proximity Read ↗

Live imaging of telomeres: yKu and Sir proteins define redundant telomere-anchoring pathways in yeast.Semantic proximity Read ↗

Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution.Semantic proximity Read ↗

Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear AssemblySemantic proximity Read ↗

PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.Semantic proximity Read ↗

Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3.Semantic proximity Read ↗

Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing.Semantic proximity Read ↗

Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin.Semantic proximity Read ↗

Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins.Semantic proximity Read ↗

The positioning of yeast telomeres depends on SIR3, SIR4, and the integrity of the nuclear membrane.Semantic proximity Read ↗

The yeast SUMO isopeptidase Smt4/Ulp2 and the polo kinase Cdc5 act in an opposing fashion to regulate sumoylation in mitosis and cohesion at centromeres.Semantic proximity Read ↗

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