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Article

T-786C single nucleotide polymorphism of the endothelial nitric oxide synthase gene as a risk factor for endothelial dysfunction in polymyalgia rheumatica.

Clinical and experimental rheumatology - 1 Jan 2000

Löffers Christine, Heilig Bernhard, Hecker Markus

Abstract excerpt

OBJECTIVES: We investigated the association of the T-786C single nucleotide polymorphism (SNP) of the endothelial nitric oxide synthase gene (NOS3), which is characterised by reduced expression of the enzyme in response to shear stress or interleukin-10 stimulation and significantly associated with coronary heart disease or rheumatoid arthritis, with the occurrence of isolated polymyalgia rheumatica. METHODS: A...

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PMID: 26314610

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NOS3

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