Article
[A gene defect in the promoter of the endothelial NO synthase as a risk factor for rheumatoid arthritis].
Zeitschrift fur Rheumatologie - 1 Jul 2007
Melchers I, Cattaruzza M
Abstract excerpt
The risk to develop rheumatoid arthritis (RA) includes environmental as well as genetic factors. Moreover, RA, being an inflammatory disease, is itself considered to be a risk factor for coronary artery disease, as it - or its treatment - may lead to endothelial dysfunction. Likewise, a single nucleotide polymorphism in the promoter of the endothelial NO synthase ((-786)C/T) leads to endothelial dysfunction in...
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