Article
Hemorheologic profile in systemic sclerosis: role of NOS3 -786T > C and 894G >T polymorphisms in modulating both the hemorheologic parameters and the susceptibility to the disease.
Arthritis and rheumatism - 1 Jul 2006
Fatini Cinzia, Mannini Lucia, Sticchi Elena, Rogai Veronica, Guiducci Serena, Conforti Maria Letizia, Cinelli Marina, Pignone Alberto Moggi, Bolli Paola, Abbate Rosanna, Cerinic Marco Matucci
Abstract excerpt
OBJECTIVE: Microvascular disorders are relevant in systemic sclerosis (SSc). Hyperviscosity, due to alterations of blood cells and plasma components, may play a role in the pathogenesis of microcirculatory disorders. An impaired availability of nitric oxide, related to polymorphisms in NOS3, the gene for endothelial cell nitric oxide synthase, might influence erythrocyte deformability. We undertook this study to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.