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Article

[Effect of Ikaros in B Cell Acute Lymphoblastic Leukemia].

Zhongguo shi yan xue ye xue za zhi - 1 Aug 2015

Zhang Hai-Ying, Bai Hai

Abstract excerpt

The Ikaros - a DNA-binding zinc finger protein, acting as a regulator of chromatin remodeling and gene transcription, is crucial for regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Function-loss mutations of IKZF1, gene encoding Ikaros are frequent in B cell acute lymphoblastic leukemia (B-ALL) and are associated with a poor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26314472
DOI: 10.7534/j.issn.1009-2137.2015.04.056

Genes

IKZF1

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