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Article

Establishment of liver tumor cell lines from atherogenic and high fat diet fed hepatitis C virus transgenic mice.

Scientific reports - 22 Jun 2021

Shirasaki Takayoshi, Murai Kazuhisa, Honda Masao, Okada Hikari, Innami Yuika, Yamada Atsumu, Shimakami Tetsuro, Kawaguchi Kazunori, Yamashita Taro, Sakai Yoshio, Kaneko Shuichi

Abstract excerpt

A syngeneic mouse model bearing a transplanted tumor is indispensable for the evaluation of the efficacy of immune checkpoint inhibitors (ICIs). However, few syngeneic mouse models of liver cancer are available. We established liver tumor cell lines (MHCF1 and MHCF5) from hepatitis C virus transgenic mice fed an atherogenic high-fat diet. MHCF1 and MHCF5 were successfully transplanted into the subcutaneous space...

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Identifiers

PMID: 34158541
DOI: 10.1038/s41598-021-92128-9
PMCID: PMC8219799

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