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Article

ZD1839 (IRESSA) stabilizes p27Kip1 and enhances radiosensitivity in cholangiocarcinoma cell lines.

Anticancer research - 1 Apr 2009

Yabuuchi Shinichi, Katayose Yu, Oda Akira, Mizuma Masamichi, Shirasou Satoru, Sasaki Tsuyoshi, Yamamoto Kuniharu, Oikawa Masaya, Rikiyama Toshiki, Onogawa Tohru, Yoshida Hiroshi, Ohtuska Hideo, Motoi Fuyuhiko, Egawa Shinichi, Unno Michiaki

Abstract excerpt

The prognosis of cholangiocarcinoma patients is extremely poor despite the aggressive multidisciplinary cancer therapies that have been used clinically (1). Recently, molecular target therapy has attracted attention. Epidermal growth factor receptor (EGFR) tyrosine kinase (TK) is a promising target for anticancer therapy. ZD1839 (IRESSA) is an orally active, selective inhibitor of EGFR-TK. This study examined the...

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Identifiers

PMID: 19414361

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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