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Article

Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing.

Hepatology (Baltimore, Md.) - 1 Oct 2012

Vetter Diana, Cohen-Naftaly Michal, Villanueva Augusto, Lee Youngmin A, Kocabayoglu Peri, Hannivoort Rebekka, Narla Goutham, M Llovet Josep, Thung Swan N, Friedman Scott L

Abstract excerpt

UNLABELLED: KLF6-SV1 (SV1), the major splice variant of KLF6, antagonizes the KLF6 tumor suppressor by an unknown mechanism. Decreased KLF6 expression in human hepatocellular carcinoma (HCC) correlates with increased mortality, but the contribution of increased SV1 is unknown. We sought to define...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22535637
DOI: 10.1002/hep.25810
PMCID: PMC3412196

Genes

KLF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22535637-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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