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Article

TRPM2, a Susceptibility Gene for Bipolar Disorder, Regulates Glycogen Synthase Kinase-3 Activity in the Brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Aug 2015

Jang Yongwoo, Lee Sung Hoon, Lee Byeongjun, Jung Seungmoon, Khalid Arshi, Uchida Kunitoshi, Tominaga Makoto, Jeon Daejong, Oh Uhtaek

Abstract excerpt

Bipolar disorder (BD) is a psychiatric disease that causes mood swings between manic and depressed states. Although genetic linkage studies have shown an association between BD and TRPM2, a Ca(2+)-permeable cation channel, the nature of this association is unknown. Here, we show that D543E, a mut...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26311765
DOI: 10.1523/JNEUROSCI.5251-14.2015
PMCID: PMC6705460

Genes

TRPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26311765-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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