Article
PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder.
The pharmacogenomics journal - 1 Apr 2007
Borsotto M, Cavarec L, Bouillot M, Romey G, Macciardi F, Delaye A, Nasroune M, Bastucci M, Sambucy J-L, Luan J-J, Charpagne A, Jouët V, Léger R, Lazdunski M, Cohen D, Chumakov I
Abstract excerpt
Many bipolar affective disorder (BD) susceptibility loci have been identified but the molecular mechanisms responsible for the disease remain to be elucidated. In the locus 4p16, several candidate genes were identified but none of them was definitively shown to be associated with BD. In this region, the PPP2R2C gene encodes the Bgamma-regulatory subunit of the protein phosphatase 2A (PP2A-Bgamma). First, we...
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