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Article

Alzheimer's disease: rare variants with large effect sizes.

Current opinion in genetics & development - 1 Aug 2015

Del-Aguila Jorge L, Koboldt Daniel C, Black Kathleen, Chasse Rachel, Norton Joanne, Wilson Richard K, Cruchaga Carlos

Abstract excerpt

Recent advances in sequencing technology and novel genotyping arrays (focused on low-frequency and coding variants) have made it possible to identify novel coding variants with large effect sizes and also novel genes (TREM2, PLD3, UNC5C, and AKAP9) associated with Alzheimer's disease (AD) risk. The major advantages of these studies over the classic genome-wide association studies (GWAS) include the identification...

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Source

Identifiers

PMID: 26311074
DOI: 10.1016/j.gde.2015.07.008

Genes

AKAP9
PLD3
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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