Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition.

British journal of haematology - 1 Nov 2015

Nicholson Lindsay, Evans Caroline A, Matheson Elizabeth, Minto Lynne, Keilty Christopher, Sanichar Maryna, Case Marian, Schwab Claire, Williamson Daniel, Rainer Johannes, Harrison Christine J, Kofler Reinhard, Hall Andrew G, Redfern Christopher P F, Whetton Anthony D, Irving Julie A E

Abstract excerpt

Glucocorticoid (GC) resistance is a continuing clinical problem in childhood acute lymphoblastic leukaemia (ALL) but the underlying mechanisms remain unclear. A proteomic approach was used to compare profiles of the B-lineage ALL GC-sensitive cell line, PreB 697, and its GC-resistant sub-line, R3F9, pre- and post-dexamethasone exposure. PAX5, a transcription factor critical to B-cell development was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dexamethasone
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase 4

Share to MAP Kinase Signaling System

Share to Multiplex Polymerase Chain Reaction

Share to PAX5 Transcription Factor

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Tandem Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 26310606
DOI: 10.1111/bjh.13647
PMCID: PMC4833193

Genes

PAX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition.PMID 26310606Read ↗

Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Targeting glucocorticoid-induced CD20 activation in preclinical models of B-ALLSemantic proximity Read ↗

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemiaSemantic proximity Read ↗

Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor.Semantic proximity Read ↗

SUMOylation inhibition potentiates the glucocorticoid receptor to program growth arrest of acute lymphoblastic leukemia cellsSemantic proximity Read ↗

Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolismSemantic proximity Read ↗

Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

PI3Kδ inhibition potentiates glucocorticoids in B-lymphoblastic leukemia by decreasing receptor phosphorylation and enhancing gene regulationSemantic proximity Read ↗

Analysis of common glucocorticoid response genes in childhood acute lymphoblastic leukemia in vivo identifies cell cycle but not apoptosis genesSemantic proximity Read ↗

Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress responseSemantic proximity Read ↗

Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.