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Article

Analysis of common glucocorticoid response genes in childhood acute lymphoblastic leukemia in vivo identifies cell cycle but not apoptosis genes

2020-07-20

Abstract excerpt

Glucocorticoids (GCs) are an essential component of acute lymphoblastic leukemia (ALL) therapy. To identify genes mediating the anti-leukemic GC effects in vivo , we performed gene expression profiling of lymphoblasts from 46 children during the first 6-24h of systemic GC mono-therapy. Differential gene expression analysis across all patients revealed a considerable number of GC-regulated genes (190 induced, 179 r...

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Literature Corpus work
d267ee95-6f0f-5590-bdc4-afb8e75ece3f
DOI
10.1101/2020.07.11.20148890
Open publication

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Analysis of common glucocorticoid response genes in childhood acute lymphoblastic leukemia in vivo identifies cell cycle but not apoptosis genesDOI 10.1101/2020.07.11.20148890
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