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Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemia

22 May 2023

Abstract excerpt

Resistance to glucocorticoids (GC) is associated with an increased risk of relapse in B-cell progenitor acute lymphoblastic leukemia (BCP-ALL). Performing transcriptomic and single-cell proteomic studies in healthy B-cell progenitors, we herein identify coordination between the glucocorticoid receptor pathway with B-cell developmental pathways. Healthy pro-B cells most highly express the glucocorticoid receptor,...

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PMID: 37217509
DOI: 10.1038/s41467-023-38456-y

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