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Article

Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2006

Schmidt Stefan, Irving Julie A E, Minto Lynne, Matheson Elizabeth, Nicholson Lindsay, Ploner Andreas, Parson Walther, Kofler Anita, Amort Melanie, Erdel Martin, Hall Andy, Kofler Reinhard

Abstract excerpt

Glucocorticoids (GCs) specifically induce apoptosis in malignant lymphoblasts and are thus pivotal in the treatment of acute lymphoblastic leukemia (ALL). However, GC-resistance is a therapeutic problem with an unclear molecular mechanism. We generated approximately 70 GC-resistant sublines from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17077285
DOI: 10.1096/fj.06-6214fje

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17077285-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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