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Article

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia

31 Aug 2015

Abstract excerpt

The outcome for pediatric acute lymphoblastic leukemia (ALL) patients who relapse is dismal. A hallmark of relapsed disease is acquired resistance to multiple chemotherapeutic agents, particularly glucocorticoids. In this study, we performed a genome-scale short hairpin RNA screen to identify mediators of prednisolone sensitivity in ALL cell lines. The incorporation of these data with an integrated analysis of...

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PMID: 26324703
DOI: 10.1182/blood-2015-04-639138

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