Article
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
The Journal of steroid biochemistry and molecular biology - 1 Apr 2022
Tamai Minori, Kasai Shin, Akahane Koshi, Thu Thao Nguyen, Kagami Keiko, Komatsu Chiaki, Abe Masako, Watanabe Atsushi, Goi Kumiko, Miyake Kunio, Inaba Toshiya, Takita Junko, Goto Hiroaki, Minegishi Masayoshi, Iwamoto Shotaro, Sugita Kanji, Inukai Takeshi
Abstract excerpt
Glucocorticoid (GC) is a key drug in the treatment of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and the initial GC response is an important prognostic factor. GC receptors play an essential role in GC sensitivity, and somatic mutations of the GC receptor gene, NR3C1, are reportedly identified in some BCP-ALL cases, particularly at relapse. Moreover, associations of somatic mutations of the...
Topics
- Glucocorticoids
- Humans
- Metabolism, Inborn Errors
- Mutation
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Receptors, Glucocorticoid
- Recurrence