Article

PI3Kδ inhibition potentiates glucocorticoids in B-lymphoblastic leukemia by decreasing receptor phosphorylation and enhancing gene regulation

2023-02-12

Abstract excerpt

<h4>ABSTRACT</h4> Glucocorticoids, including dexamethasone and prednisone, are the cornerstone of B-lymphoblastic leukemia (B-ALL) therapy. Because response to glucocorticoids alone predicts overall outcomes for B-ALL, enhancing glucocorticoid potency is a route to improving outcomes. However, systematic toxicities prevent the use of higher dose and more potent glucocorticoids. We therefore took a functional geno...

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Literature Corpus work: 84917b88-ecb7-54b2-b759-94fcbfad5598
DOI: 10.1101/2023.02.10.527869

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