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Article

Impact of Single Nucleotide Polymorphisms (SNPs) on Immunosuppressive Therapy in Lung Transplantation.

International journal of molecular sciences - 25 Aug 2015

Ruiz Jesus, Herrero María José, Bosó Virginia, Megías Juan Eduardo, Hervás David, Poveda Jose Luis, Escrivá Juan, Pastor Amparo, Solé Amparo, Aliño Salvador Francisco

Abstract excerpt

Lung transplant patients present important variability in immunosuppressant blood concentrations during the first months after transplantation. Pharmacogenetics could explain part of this interindividual variability. We evaluated SNPs in genes that have previously shown correlations in other kinds of solid organ transplantation, namely ABCB1 and CYP3A5 genes with tacrolimus (Tac) and ABCC2, UGT1A9 and SLCO1B1...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunosuppressive Agents

Share to Lung Transplantation

Share to Multidrug Resistance-Associated Protein 2

Share to Multidrug Resistance-Associated Proteins

Share to Mycophenolic Acid

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Source

Open in PubMed Open full text

Identifiers

PMID: 26307985
DOI: 10.3390/ijms160920168
PMCID: PMC4613195

Genes

ABCB1
ABCC2
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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