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Studying the mechanism of sperm DNA damage caused by folate deficiency

24 Dec 2021

Abstract excerpt

Sperm DNA injury is one of the common causes of male infertility. Folic acid deficiency would increase the methylation level of the important genes, including those involved in DNA double-strand break (DSB) repair pathway. In the early stages, we analysed the correlation between seminal plasma folic acid concentration and semen parameters in 157 infertility patients and 91 sperm donor volunteers, and found that...

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PMID: 34953021
DOI: 10.1111/jcmm.17119

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