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Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival

6 Aug 2007

Abstract excerpt

Many cells latently infected with Epstein-Barr virus (EBV), including certain virus-associated tumors, express latent membrane protein 2A (LMP2A), suggesting an important role for this protein in viral latency and oncogenesis. LMP2A mimics B-cell receptor signaling but can also act as a decoy receptor blocking B-cell receptor (BCR) activation. Studies of peripheral B cells have not resolved this apparent...

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PMID: 17682125
DOI: 10.1182/blood-2007-05-090142

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