Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of an intermediate conformer of the spindle checkpoint protein Mad2.

Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2015

Hara Mayuko, Özkan Engin, Sun Hongbin, Yu Hongtao, Luo Xuelian

Abstract excerpt

The spindle checkpoint senses unattached kinetochores during prometaphase and inhibits the anaphase-promoting complex or cyclosome (APC/C), thus ensuring accurate chromosome segregation. The checkpoint protein mitotic arrest deficient 2 (Mad2) is an unusual protein with multiple folded states. Mad2 adopts the closed conformation (C-Mad2) in a Mad1-Mad2 core complex. In mitosis, kinetochore-bound Mad1-C-Mad2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase-Promoting Complex-Cyclosome
Share to Calorimetry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cdc20 Proteins

Share to Kinetochores

Share to Mad2 Proteins

Share to Magnetic Resonance Spectroscopy

Share to Mitosis

Share to Protein Multimerization

Source

Open in PubMed Open full text

Identifiers

PMID: 26305957
DOI: 10.1073/pnas.1512197112
PMCID: PMC4568698

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of an intermediate conformer of the spindle checkpoint protein Mad2.PMID 26305957Read ↗

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet.Semantic proximity Read ↗

CDC20 assists its catalytic incorporation in the mitotic checkpoint complex.Semantic proximity Read ↗

An S752D activation loop mutation dynamically primes Muscle-Specific Kinase for activation.Semantic proximity Read ↗

Structure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control.Semantic proximity Read ↗

Mad2 phosphorylation regulates its association with Mad1 and the APC/C.Semantic proximity Read ↗

Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity.Semantic proximity Read ↗

Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human CellsSemantic proximity Read ↗

Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.Semantic proximity Read ↗

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.Semantic proximity Read ↗

The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores.Semantic proximity Read ↗

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling.Semantic proximity Read ↗

Two TPX2-dependent switches control the activity of Aurora A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.