Article
CDC20 assists its catalytic incorporation in the mitotic checkpoint complex.
Science (New York, N.Y.) - 1 Jan 2021
Piano Valentina, Alex Amal, Stege Patricia, Maffini Stefano, Stoppiello Gerardo A, Huis In 't Veld Pim J, Vetter Ingrid R, Musacchio Andrea
Abstract excerpt
Open (O) and closed (C) topologies of HORMA-domain proteins are respectively associated with inactive and active states of fundamental cellular pathways. The HORMA protein O-MAD2 converts to C-MAD2 upon binding CDC20. This is rate limiting for assembly of the mitotic checkpoint complex (MCC), the effector of a checkpoint required for mitotic fidelity. A catalyst assembled at kinetochores accelerates MAD2:CDC20...
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