Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet.

The EMBO journal - 22 Mar 2006

Mapelli Marina, Filipp Fabian V, Rancati Giulia, Massimiliano Lucia, Nezi Luigi, Stier Gunter, Hagan Robert S, Confalonieri Stefano, Piatti Simonetta, Sattler Michael, Musacchio Andrea

Abstract excerpt

The spindle assembly checkpoint (SAC) monitors chromosome attachment to spindle microtubules. SAC proteins operate at kinetochores, scaffolds mediating chromosome-microtubule attachment. The ubiquitous SAC constituents Mad1 and Mad2 are recruited to kinetochores in prometaphase. Mad2 sequesters Cdc20 to prevent its ability to mediate anaphase onset. Its function is counteracted by p31comet (formerly CMT2). Upon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mad2 Proteins
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Binding Proteins

Share to Cdc20 Proteins

Share to Dimerization

Share to Kinetochores

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Spindle Apparatus

Source

Open in PubMed Open full text

Identifiers

PMID: 16525508
DOI: 10.1038/sj.emboj.7601033
PMCID: PMC1422169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet.PMID 16525508Read ↗

Structure of an intermediate conformer of the spindle checkpoint protein Mad2.Semantic proximity Read ↗

CDC20 assists its catalytic incorporation in the mitotic checkpoint complex.Semantic proximity Read ↗

Two structurally mobile regions control the conformation and function of metamorphic meiotic HORMAD proteins.Semantic proximity Read ↗

Structure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control.Semantic proximity Read ↗

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling.Semantic proximity Read ↗

The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores.Semantic proximity Read ↗

Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity.Semantic proximity Read ↗

Site-to-site mutational dissection of fission yeast cohesin reveals its dynamics.Semantic proximity Read ↗

Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D.Semantic proximity Read ↗

14-3-3 protein binding blocks the dimerization interface of caspase-2.Semantic proximity Read ↗

Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.Semantic proximity Read ↗

Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.