Article
IL-12B Gene Polymorphisms and IL-12 p70 Serum Levels Among Patients with Rheumatoid Arthritis.
Scandinavian journal of immunology - 1 Feb 2017
Paradowska-Gorycka A, Sowinska A, Stypińska B, Haladyj E, Pawlik A, Romanowska-Próchnicka K, Olesinska M
Abstract excerpt
Rheumatoid arthritis (RA) is one of the autoimmune diseases, where different polymorphisms in cytokine genes play a pathogenic role. IL-12 is now recognized as a critical cytokine in terms of regulating the balance between Th1 and Th2 cells. We investigated the role of single nucleotide polymorphisms (SNPs) (rs3212227 (A/C) and rs17860508 (CTCTAA/GC)) of the IL-12B gene in the genetic susceptibility to RA and in...
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