Article
Therapy escape mechanisms in the malignant prostate.
Seminars in cancer biology - 1 Dec 2015
Santer Frédéric R, Erb Holger H H, McNeill Rhiannon V
Abstract excerpt
Androgen receptor (AR) is the main target for prostate cancer therapy. Clinical approaches for AR inactivation include chemical castration, inhibition of androgen synthesis and AR antagonists (anti-androgens). However, treatment resistance occurs for which an important number of therapy escape mechanisms have been identified. Herein, we summarise the current knowledge of molecular mechanisms underlying therapy...
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