Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer.

Oncotarget - 27 Sept 2016

Wadosky Kristine M, Koochekpour Shahriar

Abstract excerpt

Prostate cancer (PCa) is the most widely diagnosed male cancer in the Western World and while low- and intermediate-risk PCa patients have a variety of treatment options, metastatic patients are limited to androgen deprivation therapy (ADT). This treatment paradigm has been in place for 75 years due to the unique role of androgens in promoting growth of prostatic epithelial cells via the transcription factor...

Topics

Androgen Antagonists
Animals
Antineoplastic Agents, Hormonal
Drug Resistance, Neoplasm
Humans
Kallikreins
Male
Mutation
Neoplasm Staging
Phosphorylation
Prostate-Specific Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prostatic Neoplasms, Castration-Resistant

Receptors, Androgen

Risk Factors

Signal Transduction

Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 27487144
DOI: 10.18632/oncotarget.10901
PMCID: PMC5325456

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer.PMID 27487144Read ↗

Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical ApplicationsSemantic proximity Read ↗

Mechanisms of resistance to androgen deprivation therapy in prostate cancer.Semantic proximity Read ↗

Overcoming drug resistance in castrate-resistant prostate cancer: current mechanisms and emerging therapeutic approachesSemantic proximity Read ↗

Novel hormone therapies for advanced prostate cancer: Understanding and countering drug resistanceSemantic proximity Read ↗

Targeting the androgen receptor and overcoming resistance in prostate cancerSemantic proximity Read ↗

Molecular pathogenesis and progression of prostate cancer.Semantic proximity Read ↗

Resistance to second generation antiandrogens in prostate cancer: pathways and mechanismsSemantic proximity Read ↗

New Opportunities for Targeting the Androgen Receptor in Prostate Cancer.Semantic proximity Read ↗

Targeting androgen receptor-independent pathways in therapy-resistant prostate cancerSemantic proximity Read ↗

Androgen receptor signaling and mutations in prostate cancer.Semantic proximity Read ↗

Persistent androgen receptor addiction in castration-resistant prostate cancerSemantic proximity Read ↗

Therapy escape mechanisms in the malignant prostate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.