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Article

Mechanisms of resistance to androgen deprivation therapy in prostate cancer.

Molecular aspects of medicine - 1 Aug 2026

Bensalim Imane, Belyamani Lahcen, Boutayeb Saber, Bourais Ilhame

Abstract excerpt

Prostate cancer is among the top causes of cancer-related mortality in men, according to the latest data from GLOBOCAN, driven primarily by androgen receptor signaling and initially treated with androgen deprivation therapy. However, most patients progress to a resistant state characterized by mechanisms such as receptor amplification, mutations, splice variants, and activation of alternative pathways. This...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42314224
DOI: 10.1016/j.mam.2026.101488

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